Assessing SOD 1 Activity in Thalassemia: New insights

Abstract

Thalassemia is an inherited blood illness where there is a decrease or lack of one or more globin chains in haemoglobin, resulting in anaemia and associated problems. The disease's pathogenesis includes inadequate erythropoiesis, hemolysis, and significant oxidative stress caused by iron excess, particularly in patients receiving frequent blood transfusions. The ELISA technique was utilised to quantify the amounts of superoxide dismutase1( SOD1) in the samples under investigation. Each group comprised 10 participants. The average SOD level in the patient group was 17,856 units, with a median of 16,492 units and a standard deviation of 6,391 units. The control group had a mean SOD level of 19,915 units and a median of 13,548 units, showing a higher variability with a standard deviation of 16,874 units.